Synthesis and pharmacological evaluation of azetidin-2-ones and thiazolidin-4-ones encompassing benzothiazole
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چکیده
منابع مشابه
Synthesis and Pharmacological Evaluation of Azetidin-2-ones and Thiazolidin-4-ones Encompassing Benzothiazole
Various 7-chloro-6-fluoro-2-arylidenylaminobenzo(1,3)thiazole (2a-h) have been synthesized by the condensation of 7-chloro-6-fluoro-2-aminobenzo(1,3)thiazole (1) with different aromatic aldehydes. The Schiff's bases on reaction with acetyl chloride, chloroacetyl chloride and phenyl acetyl chloride yielded 1-(7-chloro-6-fluorobenzothiazol-2-yl)-3,4-substituted-aryl-azetidin-2-ones (3a-x). Simila...
متن کاملSynthesis and Antimicrobial Activities of Some New Azetidin-2-ones and Thiazolidin-4-ones
Various (4-substituted) phenyl-3-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]propionylamido-1,3-thiazolidine-4-ones (3a-x) and 1-β-[(N-benzenesulphonyl/tosyl)-4-(un)substituted anilino]-propionylamido-3-chloro-4-(4-substituted)phenyl-azetidin-2-ones (4a-x) have been synthesised by the cyclocondensation of Schiff bases (2a-x) with thioglycolic acid and chloroacetyl chloride, respecti...
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A new series of 2-(3-oxo-3-phenylpropanoyl)-3-(substituted aryl)-1-thiazolidin-4-ones has been synthesized by cyclocondensation of ketoanils (the condensation products of 2, 4-dioxo-4phenyl butanal with primary amines) with mercaptoacetic acid. The chemical structures of the synthesized compounds were elucidated by elemental analysis, molecular weight determination, and UV, IR, 1H, 13C and DEPT...
متن کاملSynthesis and Pharmacological Investigation of Novel 2-(3-hydroxy-4-methoxy Phenyl)- 3-substituted-thiazolidin-4-ones as Anticonvulsants
A new series of 2,3-disubstituted thiazolidin-4-ones were obtained by the condensation of appropriate amines with vanillin and mercapto acetic acid in the presence of DCC in anhydrous THF by microwave irradiation. The title compounds were investigated for their anticonvulsant activity. Among the test compounds, compound N-(2-(3hydroxy-4-methoxyphenyl)-4-oxo thiazolidin-3-yl) isonicotinamide (3)...
متن کاملSynthesis & Antifungal Screening of Novel Azetidin-2-ones
A new series of 4-[3-chloro-2-(4-hydroxy-3-methoxybenzyllidene)-4-oxoazetidin-1-yl]amino-N-(substituted) benzenesulfonamide, 4-{3-chloro-2-[5-methoxy-2-nitro-4-(prop-2-en-1-yloxy)benzyllidene]-4-oxoazetidin-1-yl}]amino}-N(substituted)benzenesulfonamide and 4-{3-chloro-2-[4-hydroxy-3-methoxy-5-(prop-2-en-1-yl)benzylidene]-4-oxoazetidin-1-yl}amino}-N-(substituted) benzenesulfonamide were synthesi...
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ژورنال
عنوان ژورنال: Indian Journal of Pharmaceutical Sciences
سال: 2008
ISSN: 0250-474X
DOI: 10.4103/0250-474x.45393